NAD+ (Nicotinamide Adenine Dinucleotide)

Category: Cellular Energy & Anti-Aging

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every living cell. It is the central electron carrier in cellular respiration and a key substrate for sirtuins (longevity proteins), PARP enzymes (DNA repair), and CD38/cyclic-ADP-ribose signaling. NAD+ levels decline 40–50% between ages 20 and 60, driving many hallmarks of aging. Supplementation via IV infusion, subcutaneous injection, or oral precursors (NMN, NR) can restore levels and is being actively studied for longevity, neurological health, metabolic disease, and addiction recovery.

Half-Life: 4 hours

Common Dosage: 250mg

Benefits

  • Boosts cellular ATP energy production (mitochondrial Complex I)
  • Activates sirtuins (SIRT1–SIRT7) — key longevity regulators
  • Enhances PARP-mediated DNA repair and genomic stability
  • Improves mitochondrial biogenesis and function
  • Increased mental clarity, focus, and cognitive performance
  • Supports addiction and withdrawal recovery (alcohol, opioids)
  • Reduces neuroinflammation and supports neuroprotection
  • May improve insulin sensitivity and metabolic health
  • Anti-aging effects via telomere maintenance support
  • Chronic fatigue and Long COVID symptom relief (emerging data)
  • Improves exercise performance and muscle recovery
  • Supports circadian rhythm regulation

Side Effects

  • Nausea (very common during IV — almost universal if infused too fast)
  • Flushing and chest pressure/tightness (IV — rate-dependent)
  • Cramping or abdominal discomfort (IV)
  • Headache (IV and oral)
  • Fatigue or "detox reaction" during first 1–3 days
  • Dizziness or lightheadedness (IV)
  • Mild injection site irritation (SubQ)
  • Insomnia if dosed later in the day (stimulating effect)
  • Transient elevation in liver enzymes (rare, high dose IV)